Copper-catalyzed alkylarylation of activated alkenes using isocyanides as the alkyl source: an efficient radical access to 3,3-dialkylated oxindoles
نویسندگان
چکیده
منابع مشابه
Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles.
An iron-catalyzed aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed, which is a rare example where a cosolvent is used to improve the reaction yield along with Fenton's reagent and thus provides an economic and green method for the synthesis of a variety of difluoromethylated oxindoles. Preliminary mechanistic investigations indicate a radical additi...
متن کاملRadical cascade cyanomethylation of activated alkenes to construct cyano substituted oxindoles.
The cyanomethyl radical was easily generated from acetonitrile by using DTBP, which was applied to a cascade alkene addition and cyclization reaction to construct useful oxindole derivatives. This protocol features simple manipulation, cheap reagents and a broad substrate scope. In addition, nitro substituted oxindoles were also synthesized for the first time.
متن کاملPd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes.
A Pd(0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed. This reaction provides a new method for construction of a variety of difluoromethylated oxindoles. Mechanistic investigations indicate that a difluoromethyl radical, which was triggered by Pd(0), initiated the cascade sequence through an addition to the alkene.
متن کاملnano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
Copper-catalyzed domino coupling reaction: an efficient method to synthesize oxindoles.
An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2016
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c6cc02024k